Is big beautiful? The continuing story of ADAM33 and asthma

Is big beautiful? The continuing story of ADAM33 and asthma.

T he gene encoding A Disintegrin And Metalloprotease (ADAM) 33 was the first asthma susceptibility gene to be discovered by positional cloning. In 460 families enriched with asthma, linkage analysis using microsatellite markers spaced ,9 cM apart revealed a region on chromosome 20p13 that carried one or more asthma genes, achieving a Maximum Lod Score (MLS) of 2.24 at 9.99 cM. The addition of f...

The genetics of obstructive lung disease: big is beautiful.

Chronic obstructive pulmonary disease (COPD) is defined as airflow obstruction that is not fully reversible. It results from abnormal inflammation following exposure to noxious particles or gases. This is typically exposure to cigarette smoke but may also include exposure to biomass fuels and some industrial dusts. COPD clusters within families, suggesting that heritable factors play a role in ...

Medical data debates: big is better? Small is beautiful?

Association of ADAM33 gene polymorphisms with allergic asthma

Objective(s): Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. Materials and Methods: This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM33 gene have been assessed in patients with allergic asthma and normal con...

Big is beautiful Bootstrapping a PoS tagger for Swedish

A statistical part-of-speech tagger trained on a one-million word Swedish corpus with validated tags was used to tag two considerably larger untagged corpora (≈ 78 and 20 million words, respectively) to bootstrap new, improved, tagger models. The new taggers all showed better accuracy both for seen and unseen words, and the best tagger had 97.02% overall accuracy evaluated on the original corpu...